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目的探讨癌细胞淋巴道转移机制,观察VEGF-C及其受体Flt-4在大鼠胃癌组织中的表达。方法用免疫组化法检测大鼠胃癌组织的癌细胞和淋巴管内皮细胞对VEGF-C和Flt-4的表达。结果VEGF-C和Flt-4在癌细胞的胞浆均可见阳性表达;淋巴管内皮细胞上仅见到Flt-4的阳性表达。结论①Flt-4与VEGF-C在胃癌细胞的表达正相关,可能与肿瘤的浸润有关。②推测VEGF-C可能通过其受体Flt-4诱导胃癌组织淋巴管发生。
Objective To investigate the mechanism of lymphatic metastasis of cancer cells and to observe the expression of VEGF-C and its receptor Flt-4 in gastric cancer tissues of rats. Methods The expressions of VEGF-C and Flt-4 in gastric cancer cells and lymphatic endothelial cells were detected by immunohistochemistry. Results The positive expression of VEGF-C and Flt-4 in the cytoplasm of the cancer cells was observed. Only the positive expression of Flt-4 was found on the lymphatic endothelial cells. Conclusions ①Flt-4 is positively correlated with VEGF-C expression in gastric cancer cells, which may be related to tumor invasion. ② It is speculated that VEGF-C may induce lymphangiogenesis in gastric cancer tissues through its receptor Flt-4.