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IL-12细胞因子家族成员包括IL-12,IL-23,IL-27和IL-35。上述家族成员具有相似的异质二聚体亚基结构,但它们的生物学功能截然不同,IL-12和IL-23是Th1、Th17促炎反应的增强剂,IL-27具有促炎和抑炎双向调节作用,而IL-35是重要的抑炎细胞因子。IL-12家族是近年来炎症和免疫学研究中一个较新且重要的标志,作为调节因子和标志物,它们与多种自身免疫性疾病的发生和发展密切相关。但IL-12家族与自身免疫性甲状腺疾病(AITD)关系的研究至今报道较少,本文拟就这方面的进展作一综述。
IL-12 cytokine family members include IL-12, IL-23, IL-27 and IL-35. The above family members have similar heterogeneous dimer subunit structures, but their biological functions are distinctly different. IL-12 and IL-23 are Th1 and Th17 pro -inflammatory enhancers. IL-27 possesses pro-inflammatory and anti-inflammatory cytokines Inflammation plays a dual regulatory role, whereas IL-35 is an important anti-inflammatory cytokine. IL-12 family is a new and important marker in inflammatory and immunological research in recent years. As a regulator and marker, IL-12 family is closely related to the occurrence and development of many autoimmune diseases. But there are few reports about the relationship between IL-12 family and autoimmune thyroid disease (AITD) so far. This article intends to review the progress in this field.