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多发性硬化是中枢神经系统慢性炎性脱髓鞘疾病,常规MR成像已能够敏感地探测病变及其随时间所发生的变化,但它不能可靠地描述和量化病变内及其周围的异常改变,而且活动期和静止期病变表现相似。MR扩散成像能够区分活动期和静止期的病变,量化脊髓内病变进展程度,提供组织受损程度的量化信息,同时有助于显示病变的动态变化、治疗后的反应、描述MS病变的进展,从而有利于研究MS不同表现型疾病的进展。本文回顾和介绍MS斑块病理改变及与MRI表现间的联系,并阐述MR扩散成像技术在脊髓MS的应用。
Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Conventional MR imaging has been able to detect lesions and their changes over time sensitively, but it can not reliably describe and quantify abnormal changes in and around lesions. And active and quiescent lesions similar. MR diffusion imaging can differentiate between active and quiescent lesions, quantify the extent of intraspinal cord lesion progression, provide quantitative information on the extent of tissue damage, and at the same time help to show the dynamic changes in the lesion, post-treatment response, describe the progression of MS lesions, Which is conducive to the study of MS different manifestations of disease progression. This review and introduction of MS plaque pathological changes and the relationship between the performance of MRI and described the application of MR diffusion imaging in spinal cord MS.