论文部分内容阅读
目的观察重度急性有机磷农药中毒患者给予阿托品与长托宁联合治疗的临床效果。方法将105例重度急性有机磷农药中毒患者作为研究对象,将其均分为A、B、C 3组,每组35例。A组给予阿托品治疗,B组给予长托宁治疗,C组给予阿托品与长托宁联合治疗,观察3组患者的临床治疗效果,中毒症状消失时间和住院时间,统计3组中间综合征、不良反应发生情况。结果 C组临床总有效率为97.1%,高于A组的60.0%和B组的82.8%(P<0.01或P<0.05);C组中毒症状消失时间和住院时间均短于A组、B组(P<0.01或P<0.05);C组中间综合征和不良反应发生率均低于A组、B组(P<0.01或P<0.05);A组与B组总有效率、中毒症状消失时间、住院时间、中间综合征和不良反应发生率比较差异均有统计学意义(P<0.05)。结论阿托品和长托宁均对急性有机磷农药中毒有效,但阿托品与长托宁联合治疗效果更好,可有效减少不良反应的发生,缩短患者的住院时间,加快患者的恢复,值得临床推广应用。
Objective To observe the clinical effect of combination of atropine and changitonine in patients with severe acute organophosphorus pesticide poisoning. Methods A total of 105 patients with severe acute organophosphorus pesticide poisoning were enrolled in this study. All patients were divided into A, B and C groups, 35 cases in each group. Group A was treated with atropine, group B was treated with penehyclidine hydrochloride, group C was treated with atropine combined with penehyclidine hydrochloride. The clinical effects, the disappearance of poisoning symptoms and length of hospital stay were observed in the three groups. Reaction occurred. Results The total clinical effective rate in group C was 97.1%, higher than 60.0% in group A and 82.8% in group B (P <0.01 or P <0.05). The disappearance time and length of hospital stay in group C were shorter than those in group A, B (P <0.01 or P <0.05). The incidences of intermediate syndromes and adverse reactions in group C were lower than those in group A and group B (P <0.01 or P <0.05). The total effective rate in group A and group B The disappearance time, hospital stay, intermediate syndrome and the incidence of adverse reactions were significantly different (P <0.05). Conclusions Both atropine and penehyclidine are effective in acute organophosphorus pesticide poisoning. However, the combination of atropine and chatonin is better, which can effectively reduce the incidence of adverse reactions, shorten the hospitalization time and accelerate the recovery of patients, which is worthy of clinical application .