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控制性超促排卵(COH)是体外受精-胚胎移植(IVF-ET)的关键步骤,但与自然周期相比较,其胚胎着床率和妊娠率仍低于自然周期,这可能和该过程中激素水平的波动有关,该过程中产生超生理剂量的雌、孕激素,可引起多种凝血相关因素的改变,与血栓的形成密切相关,由此继发的子宫内膜微循环障碍可能是影响子宫内膜容受性进而影响着床率和妊娠率的重要原因之一。COH过程中凝血和纤溶系统均有不同程度的激活,凝血因子、抗凝因子、纤溶因子、血液流变学及血管内皮功能等均有不同程度的改变,这些改变与COH中高雌、孕激素状态密切相关。
Controlled ovulation induction (COH) is a key step in in vitro fertilization-embryo transfer (IVF-ET), but its embryo implantation rate and pregnancy rate are still lower than the natural cycle compared with the natural cycle, which may be related to the process Hormonal levels of the fluctuations in the process of the production of super-physiological dose of estrogen and progesterone can cause a variety of coagulation-related changes, and thrombosis are closely related to the secondary endometrial microcirculation may be affected Endometrial receptivity and then affect the bed rate and pregnancy rate of one of the important reasons. COH coagulation and fibrinolysis system has varying degrees of activation, coagulation factors, anticoagulant factors, fibrinolysis, hemorheology and vascular endothelial function have varying degrees of change, these changes and COH in the female, pregnant Hormone status is closely related.