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采用离子交联法制备了负载表没食子儿茶素没食子酸酯(EGCG)的壳聚糖微粒(EGCG-CS-MP),研究了EGCG-CS-MP的体外释放及抗氧化特性。结果表明:EGCG-CS-MP的包封率达到51.44%,载药量为55.22mg/g。EGCG-CS-MP的体外释放行为在4h左右完成,37℃时释放速度最大,低pH会加快其释放速度而高浓度的NaCl会减缓其释放速度。EGCG-CS-MP在人工胃液中比人工肠液中更易释放,最大释放率达78.07%。EGCG-CS-MP表现出良好的铁离子还原力,且对O_2~-·和·OH均有很好的清除活性,说明EGCG-CS-MP具有良好的抗氧化性能。
The EGCG-CS-MP loaded with epigallocatechin gallate (EGCG) was prepared by ion-crosslinking method. The in vitro release and antioxidant properties of EGCG-CS-MP were studied. The results showed that the entrapment efficiency of EGCG-CS-MP reached 51.44% and the drug loading was 55.22 mg / g. The in vitro release behavior of EGCG-CS-MP was completed in about 4 h. The release rate of EGCG-CS-MP was the highest at 37 ℃. The release of EGCG-CS-MP accelerated the release of EGCG-CS-MP and the release of high concentration of NaCl slowed its release. EGCG-CS-MP is more easily released in artificial gastric juice than in artificial intestinal juice, with a maximum rate of 78.07%. EGCG-CS-MP showed good ferric ion reduction ability and good scavenging activity on O 2 - · · · · OH, indicating that EGCG-CS-MP has good anti-oxidation properties.