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国的探讨血清铁蛋白的变化对干扰素治疗慢性乙型肝炎的影响。方法采用常规方法观察48例干扰素治疗乙型肝炎患者临床疗效与血清铁蛋白水平的关系。结果血清铁蛋白的增高与肝脏病变的严重程度呈正比。在干扰素治疗的48例患者中，血清铁蛋白水平＜300ng／ml者疗效明显优于300ng／ml以上者（P＜0005），提示血清铁蛋白水平增高使患者对干扰素的反应降低，在有治疗反应的23例患者中，持续反应者与暂时反应者血清铁蛋白均值差异有显著意义（t=3．484，P＜0．005）。结论血清铁蛋白水平较高可能降低对干扰素治疗的反应性且使疗效不稳固。
Effect of Interferon on Chronic Hepatitis B in Rats. Methods The routine method was used to observe the relationship between clinical efficacy and serum ferritin level in 48 patients with interferon treatment of hepatitis B patients. Results Serum ferritin increased in proportion to the severity of liver disease. Serum ferritin levels of 300 ng / ml were significantly better than those of 300 ng / ml in the 48 interferon-treated patients (P <0005), suggesting that elevated serum ferritin levels decreased the patient’s response to interferon Among the 23 patients who responded to the therapy, there was a significant difference in mean serum ferritin between the responders and the transient responders (t = 3.484, P <0.005). Conclusions A higher serum ferritin level may reduce the response to interferon therapy and render the treatment less stable.