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目的 :研究儿童病毒性心肌炎血清心肌肌钙蛋白Ⅰ (cTnⅠ )的变化 ,探讨心肌肌钙蛋白Ⅰ在儿童病毒性心肌炎诊断中的作用。方法 :采用免疫化学发光测定法检测 2 8例病毒性心肌炎患儿及 40例非心脏疾患患儿的心肌肌钙蛋白Ⅰ ,并与肌酸磷酸激酶同工酶CK -MB比较。结果 :病毒性心肌炎患儿的心肌肌钙蛋白Ⅰ(1 .2 4± 0 .46)明显高于非心脏疾患患儿 (0 .49± 0 .2 8) ,(P <0 .0 1 )。且病毒性心肌炎患儿经心肌营养治疗后心肌肌钙蛋白Ⅰ显著降低 ,而CK -MB变化不显著。结论 :心肌肌钙蛋白Ⅰ是诊断儿童病毒性心肌炎的敏感、特异、有价值的实验室指标
Objective: To study the changes of serum cardiac troponin Ⅰ (cTn Ⅰ) in children with viral myocarditis and to explore the role of cardiac troponin Ⅰ in the diagnosis of viral myocarditis in children. Methods: The levels of cardiac troponin I in 28 children with viral myocarditis and 40 children with noncardiac heart disease were detected by immunochemical chemiluminescence assay and compared with creatine kinase CK-MB. Results: The level of cardiac troponin Ⅰ (1.24 ± 0.46) in children with viral myocarditis was significantly higher than that in non-heart disease children (0.49 ± 0.28, P <0.01) . Cardiac troponin I was significantly decreased in patients with viral myocarditis after myocardial nutrition treatment, while CK-MB did not change significantly. Conclusion: Cardiac troponin Ⅰ is a sensitive, specific and valuable laboratory marker for the diagnosis of viral myocarditis in children