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目的:研究分析妊娠妇女血清总同型半胱氨酸(tHcy)、叶酸(FA)、维生素B12(Vit B12)水平以及与其相关疾病的关系。方法:选择正常妊娠285例、妊娠期高血压疾病81例、其他不良妊娠37例、非孕育龄健康对照98例,分别以比色法测定血清tHcy水平;化学发光法测定FA、Vit B12水平。结果:正常妊娠妇女tHcy、FA、Vit B12水平显著低于正常对照,差异有统计学意义(P<0.05或P<0.01);妊娠期高血压疾病、不良妊娠tHcy水平显著增高且与正常对照相比,差异有统计学意义(P<0.05);而妊娠期高血压疾病FA、Vit B12水平与正常妊娠相比,差异无统计学意义(P>0.05);不良妊娠FA、Vit B12水平与正常妊娠相比差异有统计学意义(P<0.05)。结论:妊娠期高血压疾病、不良妊娠血清tHcy水平显著增高;低水平FA、Vit B12可能是不良妊娠的重要因素之一。
Objective: To study the relationship between serum total homocysteine (tHcy), folic acid (FA), vitamin B12 (Vit B12) and related diseases in pregnant women. Methods: 285 cases of normal pregnancy, 81 cases of hypertensive disorder complicating pregnancy, 37 cases of other unwanted pregnancies and 98 cases of non-gestational healthy controls were selected. Serum tHcy level was measured by colorimetric method respectively. The levels of FA and Vit B12 were determined by chemiluminescence. Results: The levels of tHcy, FA and Vit B12 in normal pregnant women were significantly lower than those in normal controls (P <0.05 or P <0.01). The levels of tHcy in gestational hypertension and adverse pregnancy were significantly higher than those in normal controls (P <0.05). However, the levels of FA, Vit B12 in hypertensive disorder complicating pregnancy were not significantly different from those in normal pregnancy (P> 0.05). The levels of FA and Vit B12 in normal pregnancy were significantly higher than those in normal pregnancy The difference was statistically significant (P <0.05). Conclusion: The levels of tHcy in pregnant women with gestational hypertension and unhealthy pregnancy are significantly higher. Low FA and Vit B12 may be one of the important factors of adverse pregnancy.