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[目的]观察黄芪联合标准方案治疗小儿原发性肾病综合征疗效。[方法]使用随机平行对照方法,将100例住院患者按随机数字表法随机分为两组。对照组50例强的松(1.5~2mg/(kgd),≤60mg/d),分3次/d,口服,定期规律减量;低分子右旋糖酐扩容、氢氯噻嗪及螺内酯利尿、双密达莫抗凝及阿洛西林抗感染等对症支持治疗;激素无效者加用环磷酰胺(累积剂100~200mg/kg)或雷公藤多甙片(1~1.52mg/(kgd),累积量75~120 mg/kg)。治疗组50例黄芪颗粒,<3岁,0.5包/;>3岁,1包/次,2次/d;西药治疗同对照组。两组均连续治疗6个月为1疗程。观测临床症状、水肿消退时间、尿蛋白转阴时间、不良反应。治疗1疗程,判定疗效。[结果]治疗组治愈20例,显效16例,有效8例,无效6例,总有效率88.00%。对照组痊愈9例,显效8例,有效11例,无效22例,总有效率56.00%。治疗组疗效优于对照组(P<0.05)。水肿消退时间及尿蛋白转阴时间治疗组优于对照组(P<0.05)。[结论]黄芪联合标准方案治疗小儿原发性肾病综合征效果显著,值得推广。
[Objective] To observe the curative effect of astragalus combined with standard regimen on children with primary nephrotic syndrome. [Methods] Randomized parallel method was used to divide 100 inpatients randomly into two groups according to the random number table method. 50 cases of prednisone (1.5 ~ 2mg / (kgd), ≤60mg / d) in the control group were given oral and regular decrements 3 times / d; low molecular weight dextran dilation, hydrochlorothiazide and spironolactone diuretic, Coagulation and azlocillin anti-infection symptomatic and supportive treatment; hormone ineffective plus cyclophosphamide (cumulative dose of 100 ~ 200mg / kg) or Tripterygium tablets (1 ~ 1.52mg / (kgd), the cumulative amount of 75 to 120 mg / kg). The treatment group, 50 cases of Astragalus particles, <3 years old, 0.5 pack /;> 3 years old, 1 pack / time, 2 times / d; Western medicine treatment with the control group. Both groups were treated for 6 months as a course of treatment. Observation of clinical symptoms, edema subsided time, urinary protein to negative time, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] The treatment group cured 20 cases, markedly effective in 16 cases, effective in 8 cases, 6 cases, the total effective rate was 88.00%. The control group recovered in 9 cases, markedly effective in 8 cases, effective in 11 cases, ineffective in 22 cases, the total effective rate was 56.00%. The treatment group was better than the control group (P <0.05). Edema disappear time and urinary protein to negative time treatment group than the control group (P <0.05). [Conclusion] Astragalus combined with standard treatment of children with primary nephrotic syndrome effect is significant, it is worth promoting.