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目的分析无创呼吸机联合纳洛酮治疗老年慢性阻塞性肺疾病(COPD)并发Ⅱ型呼吸衰竭的临床疗效。方法将86例COPD合并Ⅱ型呼吸衰竭患者随机分为观察组43例和对照组43例。在常规治疗的基础上,对照组行无创呼吸机治疗,观察组行无创呼吸机联合纳洛酮治疗。治疗前后,监测并统计两组患者的血气指标和肺功能指标。结果治疗3 d后,两组患者的呼吸频率(R)、血氧饱和度(Sa O2)、血氧分压(Pa O2)、二氧化碳分压(Pa CO2)较治疗前均改善(P<0.05),但观察组患者Sa O2、Pa O2、Pa CO2的改善幅度均大于对照组(P<0.05);治疗3 d后,两组患者用力肺活量(FVC)、FFV1%(第1 s用力肺活量/FVC)较治疗前均改善(P<0.05),但观察组患者各指标的改善幅度均大于对照组(P<0.05)。结论无创呼吸机联合纳洛酮治疗老年COPD并发Ⅱ型呼吸衰竭的临床疗效显著。
Objective To analyze the clinical efficacy of noninvasive ventilator combined with naloxone in the treatment of senile chronic obstructive pulmonary disease (COPD) complicated with respiratory failure. Methods Totally 86 COPD patients with type Ⅱ respiratory failure were randomly divided into observation group (43 cases) and control group (43 cases). On the basis of routine treatment, the control group received noninvasive ventilator treatment and the observation group received noninvasive ventilator combined with naloxone. Before and after treatment, the blood gas indexes and lung function indexes of the two groups were monitored and counted. Results After 3 days of treatment, respiratory rate (R), blood oxygen saturation (PaO2) and carbon dioxide partial pressure (Pa CO2) in both groups were significantly improved compared with before treatment (P <0.05 ). However, the improvement rates of Sa O2, Pa O2 and Pa CO2 in the observation group were significantly higher than those in the control group (P <0.05). After 3 days of treatment, the forced vital capacity (FVC), FFV1% FVC) were improved compared with that before treatment (P <0.05), but the improvement of each index in the observation group was greater than that in the control group (P <0.05). Conclusion Noninvasive ventilator combined with naloxone in the treatment of elderly patients with COPD type Ⅱ respiratory failure was significantly effective.