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多颗粒系统是由多个剂量单元组成的给药系统,常见类型包括小丸装胶囊、微丸压片、迷你片及其他普通颗粒等。和普通单剂量单元制剂相比,多颗粒产品有较大的优势,表现在产品可以均匀地分布在胃肠道、减少对胃肠道的刺激、降低个体差异和剂量突释、生物利用度高及适用于复方以及儿科制剂等方面,现已逐渐成为产品开发的热点。同时,多颗粒系统也面临一些挑战,如生产设备的限制、生产步骤长、影响因素多、潜在的愈合及稳定性问题等。
Multiparticulate systems are dosing systems consisting of multiple dosage units. Common types include pellets, pellets, mini tablets and other common particles. Multi-particle products have major advantages over conventional single-dose cell formulations in that the product can be evenly distributed in the gastrointestinal tract, reduce gastrointestinal irritation, reduce individual differences and dose burst, and provide high bioavailability And for compound and pediatric preparations, etc., has now become a hot product development. At the same time, multiparticulate systems also face challenges such as restrictions on production equipment, long production steps, many influencing factors, potential healing and stability issues.