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自1993年10月至1995年12月，对6O例儿童急性淋巴细胞性白血病（ALL）采用大剂量氨甲喋吟十鞘内注射十甲酰四氢叶酸钙解救（HDMTX＋IT十FC）方法预防髓外白血病，大大降低了中枢神经系统白血病的发生率6％）。但有1例患儿在第3次采取常规剂量和方法的HDMTX＋IT＋FC化疗时，出现严重的中枢神经毒性。一旦发生CNSL后，即使重新加强全身化疗、头颅放疗及HDMTX应用，仍出现高CNSL复发率和骨髓复发。结论：①HDMTX＋IT＋FC方法预防髓外白血病效果肯定，但应警惕中枢神经毒性的发生。②CNSL重在预防，一旦发生，疗效差，预后不良。
From October 1993 to December 1995, 6O children with acute lymphoblastic leukemia (ALL) were treated with a high-dose methotrexate tenonin rescue (HDMTX + IT10 FC) Leukemia, greatly reduced the incidence of central nervous system leukemia 6%). However, one child developed severe CNS toxicity at the third HDMTX + IT + FC chemotherapy at the usual dose and method. In the event of CNSL, a high rate of CNSL recurrence and bone marrow recurrence persists, even with reinstatement of systemic chemotherapy, cephalic radiotherapy, and HDMTX. Conclusion: ① HDMTX + IT + FC method to prevent extra-cellular leukemia positive effect, but should be alert to the occurrence of central neurotoxicity. ②CNSL emphasis on prevention, in the event of poor efficacy, poor prognosis.