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1980年,Kyle等[1]首先发现6例符合多发性骨髓瘤(multiple myeloma,MM)诊断标准,但没有多发性骨髓瘤相关临床症状,未接受任何化疗,5年以上疾病仍处于稳定状态的患者,将其命名为冒烟型多发性骨髓瘤(smoldering multiple myeloma,SMM)。意义不明的单克隆球蛋白血症(monoclonal gammopathy of unknown significance,MGUS)也是一种无症状的浆细胞病,MGUS及SMM均是一种老年性疾病,50
In 1980, Kyle et al [1] first found that 6 cases met the multiple myeloma (MM) diagnostic criteria, but no clinical symptoms associated with multiple myeloma, without any chemotherapy, more than 5 years the disease is still in a stable state Patient, named smoldering multiple myeloma (SMM). Unidentified monoclonal gammopathy of unknown significance (MGUS) is also an asymptomatic plasma cell disease, and both MGUS and SMM are senile conditions, 50