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免疫抑制因子是一类调节免疫应答的重要细胞因子,主要来源于T 细胞、B 细胞、单核细胞和巨噬细胞。目前采用饱和硫酸铵沉淀、凝胶过滤以及高效液相色谱等技术对大部分免疫抑制因子进行了纯化,其中少数几种抑制因子cDNA 克隆和表达成功。免疫抑制因子的作用机理较为复杂,主要是通过细胞表面相应受体以及影响其它的细胞表面标记和基因表达水平方面起作用。免疫抑制因子作为一类免疫应答的调节因子,不仅在基础免疫中有着重要意义,而且同临床免疫学的关系也十分密切。
Immunosuppressive factors are a class of important cytokines that regulate immune responses, mainly from T cells, B cells, monocytes and macrophages. At present, most immunosuppressive factors are purified by saturated ammonium sulfate precipitation, gel filtration and high performance liquid chromatography, and a few of them are cloned and expressed successfully. The mechanism of action of immunosuppressive agents is more complex, mainly through the corresponding receptors on the cell surface and affecting other cell surface markers and gene expression levels. As a regulator of immune response, immunosuppressive factors are not only important in basic immunity, but also have a close relationship with clinical immunology.