1974年10月在美国加州圣地牙哥发生一次和HBsAg有关的急性肝炎暴发流行。最初是一炊事员患病,吃了他在患病前驱期时制作的食物之后3～6周内,136人的转氨酶上升,其中83％有黄疸,17％无黄疸。于急性期收集粪便标本,以免疫电镜检查甲型肝炎抗原颗粒。并对一系列血清标本检查对甲型肝炎抗原的抗体(抗HA)。 In October 1974, an outbreak of hepatitis B-related acute hepatitis occurred in San Diego, California, USA. Initially, a cook was sick and consumed 136 of the aminotransferases that rose during the first 3 to 6 weeks after his pre-birth food, 83% with jaundice and 17% without jaundice. Stool specimens were collected in acute phase and hepatitis A antigen particles were examined by immunoelectron microscopy. Antibodies against hepatitis A (HA) were examined against a series of serum samples.