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目的:观察美托洛尔对高血压并慢性心衰(CHF)患者的心功能影响及临床疗效。方法:择高血压并高心病或冠心病60例,心功能Ⅱ～Ⅳ级的患者,随机分为两组,常规组(30例),给与控制血压、利尿、转换酶抑制剂(ACEI)、洋地黄治疗。美托洛尔组(30例),在常规治疗基础上加用美托洛尔。结果:美托洛尔组临床显效率(66.7%),总有效率(93.4%),较常规组显著提高(P<0.05)。美托洛尔组与常规组治疗前后,心率、血压、左室舒张末期直径、左室收缩末期直径、左室射血分数、心输出量、E/A、等容舒张期时间均有显著改善(美托洛尔组P<0.01,常规组P<0.05),且美托洛尔组上述指标改善更明显(P<0.01或P<0.05)。结论:美托洛尔显著改善高血压并慢性心力衰竭患者的心功能,是一种安全有效的治疗方法。
Objective: To observe the effect of metoprolol on heart function and clinical efficacy in patients with hypertension and chronic heart failure (CHF). Methods: Sixty patients with high blood pressure and high heart disease or coronary heart disease, and patients with heart function Ⅱ ~ Ⅳ were randomly divided into two groups. The patients in the conventional group (30 cases) were given control of blood pressure, diuretic, ACEI, , Digitalis treatment. Metoprolol group (n = 30) received metoprolol plus conventional treatment. Results: The clinical effective rate (66.7%) and total effective rate (93.4%) in metoprolol group were significantly higher than those in conventional group (P <0.05). Metoprolol group and conventional group before and after treatment, heart rate, blood pressure, left ventricular end-diastolic diameter, left ventricular end systolic diameter, left ventricular ejection fraction, cardiac output, E / A, isovolumic diastolic time were significantly improved (P <0.01 in metoprolol group and P <0.05 in conventional group), and the above indexes in metoprolol group improved more obviously (P <0.01 or P <0.05). Conclusion: Metoprolol can significantly improve heart function in patients with hypertension and chronic heart failure. It is a safe and effective treatment.