钙粘附蛋白E是钙粘附蛋白家族中的重要成员之一,其表达与多种肿瘤的生物学行为密切相关。近年的研究发现该蛋白与肺癌的类型、分期、分级、转移和预后有关,该蛋白低表达有可能成为肺癌的诊断指标和预后不良的预警信号。同时也有可能成为肺癌治疗的新靶点。 Cadherin E is one of the important members of the cadherin family and its expression is closely related to the biological behavior of many tumors. Recent studies have found that the protein is related to the type, staging, grading, metastasis and prognosis of lung cancer. The low expression of the protein may become a diagnostic indicator of lung cancer and a prognostic signal of poor prognosis. It is also possible to become a new target for the treatment of lung cancer.