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[目的]检测乙型肝炎病毒感染者血清中可溶性Fas(sFas)及可溶性Fasligand(sFasL)水平,分析其与肝细胞炎症程度的关系.[方法]选择行肝穿刺患者60例(男性为46例,女性为14例),其中住院的慢性乙型肝炎患者为30例,门诊就诊乙型肝炎病毒携带者为30例,另选择正常人30例(男性为23例,女性为7例)列入对照组.给所有对象进行肝功能检测,对乙型肝炎及携带者进行肝穿刺,分型.[结果]慢性乙型肝炎组患者血清sFas值明显高于携带者组及对照组,血清sFasL值明显低于携带者组.慢性乙型肝炎组门静脉周围、肝小叶及门静脉炎症程度在中度以上患者血清中sFas值较对照组明显增高,肝纤维化轻、中、重度患者血清中sFas值较对照组亦均明显增高.[结论]血清sFas值的变化可反映肝组织的炎症程度.
[Objective] To detect the levels of soluble Fas (sFas) and soluble Fasligand (sFasL) in sera of patients with hepatitis B virus infection and analyze its relationship with the degree of hepatocellular inflammation. [Methods] Sixty patients (46 males , And 14 women), of which 30 were hospitalized with chronic hepatitis B, 30 were hepatitis B virus carriers in outpatient setting, and 30 were selected as normal (23 males and 7 females) Control group.All subjects were tested for liver function, liver biopsy and typing were performed on hepatitis B and carriers.Results Serum sFas levels in patients with chronic hepatitis B were significantly higher than those in carriers and controls Significantly lower than the carrier group.Chronic hepatitis B group of portal vein around the hepatic lobules and portal vein inflammation in patients with moderate or more serum sFas values were significantly higher than the control group, mild, moderate, severe serum levels of sFas in patients with liver fibrosis The control group also significantly increased. [Conclusion] Changes in serum sFas values reflect the degree of inflammation in the liver tissue.