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作者对217名医院乙型肝炎高危工作人员作了德国乙型肝炎疫苗免疫性试验,通过测定抗-HBs效价来探讨两种免疫程序、不同年龄和性别对免疫原性的影响。受种者平均年龄34岁(20～61岁)。接种前,血清中各项乙型肝炎指标及抗-HBs和抗-HBc均为阴性。受种者分为A、B两组,接种3针疫苗(疫苗是将提纯的22nm HBsAg颗粒吸附于氢氧化铝佐剂制成)。头两针间隔1个月,于第1针后5个月接种第3针。A组每次接种42μgHBsAg;B组第1次接种84μg,第2和第3次各接种21μg。3针后抗-HBs效价低于50IU
The author of 217 hospitals in high-risk hepatitis B workers made the German Hepatitis B vaccine immunity test by measuring anti-HBs titer to explore the two immunization programs, different age and gender on immunogenicity. The average recipient age of 34 years (20 to 61 years old). Before inoculation, the serum hepatitis B indicators and anti-HBs and anti-HBc were negative. The recipients were divided into groups A and B and vaccinated with a 3-dose vaccine (the vaccine was made by adsorbing purified 22 nm HBsAg particles into aluminum hydroxide adjuvant). The first two needles are separated by 1 month, and the 3rd needles are given 5 months after the first needles. In group A, 42 μg HBsAg was inoculated each time; in group B, 84 μg was inoculated for the first time, and 21 μg in the second and third inoculations. Anti-HBs titres of less than 50 IU after 3 pins