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采用大剂量（每次120mg／m2）顺铂（PDD）对13例膀胱癌患者定期施行4～6次膀胱灌注，获得较好疗效，10例浅表性膀胱癌基本消退；2例浸润性膀胱癌，1例肿瘤基本消退，1例中断灌注；1例结肠腺性细胞转移癌患者3个月后死于肝转移。除并发严重血尿外，无其他毒副作用。随访30个月以上，复发率为4．8％。认为大剂量PDD膀胱铂灌注既有预防性作用，也有治疗性作用；既有直接杀伤癌细胞的作用，也有增强机体免疫能力的作用；但使用大剂量PDD应持慎重态度，严防出血。
Thirteen patients with bladder cancer were treated with high-dose (120mg / m2) cisplatin (PDD) once a day for 6 to 6 weeks, and good curative effect was obtained. Ten patients with superficial bladder cancer subsided. Two patients with invasive bladder One patient had a regression of cancer and one patient had an interruption of perfusion. One patient with colonic adenocarcinoma died of liver metastasis after 3 months. In addition to severe hematuria, no other side effects. Follow-up more than 30 months, the recurrence rate was 4.8%. It is considered that high-dose PDD bladder platinum infusion has both preventive and curative effects. It not only can directly kill cancer cells but also enhances the immune function of the body. However, high dose PDD should be used with caution to prevent bleeding.