回想上个世纪末,人类基因组计划完成之时,我们就为人类伟大智慧而感到骄傲。如今,十几年过去了,这棵智慧树不断开枝散叶,散发着它独特的芳香。在基因组计划完成之后,出现了各种组学(omics)研究,即转录组学、蛋白组学和代谢组学。而代谢组学在短暂的十年内迅速发展,代谢组学的出现标示着人类代谢研究迎来了新的辉煌时期。1999年,Nicholson教授首次提出了代谢组学的概念: Looking back at the end of the last century, when the Human Genome Project was completed, we were proud of the great wisdom of mankind. Today, a dozen years have passed, and this tree of knowledge has been constantly opening branches and leaves, exuding its unique aroma. Following the completion of the genome project, various omics studies have emerged, namely transcriptomics, proteomics and metabolomics. The rapid development of metabonomics in a short period of ten years, the emergence of metabonomics indicates that human metabolism ushered in a new period of glory. In 1999, Professor Nicholson first proposed the concept of metabonomics: