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综述了天然双环核苷、抗病毒构效研究中的双环核苷和反义寡核苷酸领域中双环及三环核苷的合成研究进展,介绍了常规官能团转化法及近年来出现的自由基环合、1,3-偶极环加成和烯烃复分解等新方法。
The progress in the synthesis of bicyclic and tricyclic nucleosides in bicyclic nucleosides and antisense oligonucleotides in the field of natural bicyclic nucleosides and antiviral structure-activity studies is reviewed. The conventional functional group transformation and the recent emergence of free radicals Cyclization, 1,3-dipolar cycloaddition and olefin metathesis and other new methods.