18岁以上的囊性纤维化(CF)患者半数以上出现葡萄糖耐受异常,且有15％出现空腹高糖血症。尽管有间接证据显示CF时组织的胰岛素敏感性升高,葡萄糖不耐受看来还是胰岛素分泌减少之故。然而,CF时胃肠道及肝可能异常,使得葡萄糖耐受常规试验很难得到解释。作者应用最近建立的持续葡萄糖输注结合模型评价法(Continuous in-fusion of glucose with model assessment,CIGMA)对非糖尿病CF年轻患者的β细胞功能及胰岛素敏感性进行了评价。还测定了血浆C肽以评价β细胞功能,测定血浆胰岛素以评价胰岛素敏感性。 病人与方法:非糖尿病男性及女性患者各4名, More than half of patients with cystic fibrosis (CF) over 18 years old had abnormal glucose tolerance and 15% had fasting hyperglycemia. Despite indirect evidence of elevated insulin sensitivity in CFs, glucose intolerance appears to be a reduction in insulin secretion. However, the gastrointestinal tract and liver may be abnormal at CF, making it difficult to interpret glucose tolerance in routine trials. The authors evaluated the β-cell function and insulin sensitivity in non-diabetic CF young patients using the recently established Continuous in-fusion of glucose with model assessment (CIGMA). Plasma C-peptide was also measured to assess β-cell function, and plasma insulin was measured to assess insulin sensitivity. Patients and Methods: Non-diabetic male and female patients each 4,