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目的探讨nueropilin-1(NRP-1)在非小细胞肺癌(NSCLC)中的表达及临床意义。方法应用免疫组化SP法检测68例NSCLC及癌旁组织中NRP-1的表达,分析其表达与NSCLC临床病理参数之间的关系。结果 NSCLC组织中NRP-1阳性表达率明显高于癌旁组织(P<0.05)。NRP-1在NSCLC组织中的表达与肿瘤直径、P-TNM分期及淋巴结转移密切相关(P<0.05)。结论 NRP-1过度表达在NSCLC发生、发展过程中起重要作用,可能与NSCLC发生侵袭和转移密切相关。
Objective To investigate the expression and clinical significance of nueropilin-1 (NRP-1) in non-small cell lung cancer (NSCLC). Methods Immunohistochemical SP method was used to detect the expression of NRP-1 in 68 cases of NSCLC and its adjacent tissues. The relationship between the expression of NRP-1 and clinicopathological parameters of NSCLC was analyzed. Results The positive rate of NRP-1 in NSCLC tissues was significantly higher than that in adjacent non-cancerous tissues (P <0.05). The expression of NRP-1 in NSCLC tissues was closely related to tumor diameter, P-TNM stage and lymph node metastasis (P <0.05). Conclusion NRP-1 overexpression plays an important role in the development and progression of NSCLC, which may be closely related to the invasion and metastasis of NSCLC.