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目的:探析胃癌组织中Bmi-1蛋白表达与胃癌患者病理因素以及预后的相关性。方法:对58例行胃癌切除术的患者的手术标本进行免疫化学组织染色法进行检查,检查胃癌组织中Bmi-1蛋白的表达。结果:58例患者的Bmi-1蛋白表达阳性数量为40例,阳性率为68.97%,病灶大小、浸润程度、淋巴结转移与否、癌症分期与Bmi-1蛋白表达具有相关性,P<0.05。Bmi-1蛋白表达呈阳性与阴性患者死亡率和平均生存期的差异对比(P<0.05)。结论:胃癌组织中Bmi-1蛋白表达与胃癌的复发、转移等因素显著相关,能够作为判断患者预后情况的重要指标。
Objective: To investigate the relationship between the expression of Bmi-1 protein in gastric cancer and the pathological factors and prognosis in patients with gastric cancer. Methods: Fifty-eight surgical specimens of patients with gastric cancer underwent immunohistochemical staining to examine the expression of Bmi-1 protein in gastric cancer. Results: The positive expression rate of Bmi-1 protein in 58 cases was 68.97%. There was a correlation between the expression of Bmi-1 protein and the size of tumor, infiltration degree, lymph node metastasis or not (P <0.05). Bmi-1 protein expression was positive and negative in patients with mortality and the average survival difference compared (P <0.05). Conclusion: The expression of Bmi-1 protein in gastric cancer is significantly correlated with the recurrence and metastasis of gastric cancer, which can be used as an important index to judge the prognosis of patients.