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目的:比较黄芩苷镁盐和黄芩苷的肠吸收动力学和药代动力学的异同。方法:采用高效液相色谱法(HPLC)测定样品中黄芩苷镁盐和黄芩苷的含量,计算黄芩苷镁盐的吸收速率常数(K_a),每小时单位体积的肠吸收量(Abs),表观渗透系数(P_(app))等肠吸收动力学參数和药时曲线下面积(AUQ_(0-t))等药动学参数,明确黄芩苷镁盐的肠吸收动力学和药动学特征。通过SPSS 19.0软件进行数据分析,探讨黄芩苷镁盐与黄芩苷在体和体内的吸收差异。结果:肠吸收动力学结果表明黄芩苷镁盐的K_a为黄芩苷的16.33倍,Abs为黄芩背的1.78倍,P_(app)为黄芩苷的15.75倍,统计学差异明显(P<0.05)。但药动学数据显示黄芩苷镁盐的药峰浓度(C_(max)),AUC_(0-t),达峰时间(T_(max))和血浆清除率(CL_z)与黄芩苷比较均无统计学差异。结论:与黄芩苷比较,黄芩苷镁盐在大鼠肠道的吸收更好,且吸收迅速。黄芩苷镁盐灌胃给药后药动学特征与黄芩苷无显著性差异,原因是黄芩苷镁盐经体内胃酸的作用被还原成为了黄芩苷。
Objective: To compare the intestinal absorption kinetics and pharmacokinetics of baicalin magnesium salt and baicalin. Methods: The contents of baicalin and baicalin in samples were determined by high performance liquid chromatography (HPLC), and the absorption rate constants (K a) of baicalin magnesium salts, intestinal absorption per unit volume (Abs) (P_ (app)) and other pharmacokinetic parameters such as the area under the curve (AUQ_ (0-t)), the intestinal absorption kinetics and pharmacokinetics of baicalin magnesium salt feature. Data analysis by SPSS 19.0 software to explore baicalin and baicalin absorption of baicalin in vivo and in vivo differences. Results: The results of intestinal absorption kinetics showed that K_a of baicalin magnesium salt was 16.33 times of that of baicalin, Abs was 1.78 times of baicalin and P_ (app) was 15.75 times of baicalin, the difference was statistically significant (P <0.05). However, the pharmacokinetic data showed that there was no difference between baicalin and baicalin in Baicalin (C max), AUC 0-t, T max and CL_z Statistical differences. Conclusion: Compared with the baicalin, baicalin magnesium salt in the intestine of rats better absorption, and rapid absorption. Baicalin magnesium after gavage pharmacokinetic characteristics and baicalin no significant difference, because baicalin magnesium salt by the role of the stomach acid was reduced to baicalin.