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目的检测细胞外信号调节激酶1/2(总ERK1/2)及磷酸化ERK1/2(p-ERK1/2)在血管瘤组织中的表达并探讨其意义。方法应用免疫印迹法检测10例增生期血管瘤组织和8例退化期血管瘤组织总ERK1/2及p-ERK1/2的蛋白表达。结果增生期血管瘤组织总ERK1/2的蛋白表达(0.87±0.14)与退化期血管瘤组织总ERK1/2的蛋白表达(0.79±0.05)差异无统计学意义(P>0.05);增生期血管瘤组织p-ERK1/2的蛋白表达(0.44±0.04)明显高于与退化期血管瘤组织p-ERK1/2的蛋白表达(0.23±0.08),差异有统计学意义(P<0.01)。结论血管瘤增生与ERK活性增高及ERK通路激活有关。
Objective To detect the expression of extracellular signal-regulated kinase 1/2 (total ERK1/2) and phosphorylated ERK1/2 (p-ERK1/2) in hemangiomas and explore its significance. Methods The expression of ERK1/2 and p-ERK1/2 proteins in 10 proliferative hemangiomas and 8 degenerate hemangiomas were detected by Western blotting. Results The protein expression of total ERK1/2 in proliferative hemangiomas (0.87±0.14) was not significantly different from that of total ERK1/2 in degenerating hemangiomas (0.79±0.05) (P>0.05); proliferative vessels The protein expression of p-ERK1/2 in tumor tissue (0.44±0.04) was significantly higher than that of p-ERK1/2 protein in the degenerating hemangiomas (0.23±0.08), and the difference was statistically significant (P<0.01). Conclusion Hemangioma hyperplasia is associated with increased ERK activity and activation of ERK pathway.