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轻型哮喘吸入溴化异丙阿托品的疗效几乎与吸入舒喘灵或异丙肾上腺素相仿。在急性严重哮喘,雾化吸入异丙阿托品后,其平均最大呼气流速(peakexpiratory flow rate,PEFR)增加与舒喘灵相似,约为50%。上述两种药物间隔2小时顺序给予时,支气管扩张作用更大,用药后4小时内 PEFR 增加1倍,并不受给药顺序影响。使用异丙阿托品和舒喘灵所取得的效益似乎跟两药作用途径不同有关。本文观察连续2次给予同一药物的最大剂量是否能取得更好结果。
Inhaled bronchial asthma is almost as effective as inhaled salbutamol or isoproterenol. In acute severe asthma, the mean maximum expiratory flow rate (PEFR) increases similar to salbutamol at approximately 50% after nebulization of isopropyralin. Bronchodilatory effects were greater when the two drugs were given sequentially at 2-hour intervals, with a 1-fold increase in PEFR within 4 hours of treatment, independent of the order of administration. The benefits of using isoprenaline and salbutamol appear to be related to the different routes of action of the two drugs. This article observes whether two consecutive doses of the same drug give better results.