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目的研究丁苯酞对急性脑梗死患者血清C-反应蛋白(CRP)的影响,探讨其在急性脑梗死早期治疗中的作用。方法将2005年1月至2006年8月河北医科大学第三医院老年病科收治的急性脑梗死患者68例随机分为丁苯酞组及常规治疗组,分别在确诊后24h内和治疗2周时测定血清CRP。另选20名健康体检者为正常对照组。结果急性脑梗死患者血清CRP质量浓度明显高于正常对照组,2组比较差异有显著性意义(P<0.01);治疗2周后CRP均显著下降,且丁苯酞组低于常规治疗组,2组比较差异有显著性意义(P<0.01)。结论早期应用丁苯酞可以显著降低急性脑梗死患者血清CRP质量浓度,减轻炎症反应,对改善脑梗死病情及预后具有重要价值。
Objective To investigate the effect of butylphthalide on serum C-reactive protein (CRP) in patients with acute cerebral infarction and its role in the early treatment of acute cerebral infarction. Methods Sixty-eight patients with acute cerebral infarction who were admitted to Department of Geriatrics, the Third Hospital of Hebei Medical University from January 2005 to August 2006 were randomly divided into butylphthalide group and conventional treatment group. After 24 hours of diagnosis and 2 weeks of treatment Serum CRP was measured. Another 20 healthy people were normal control group. Results Serum CRP levels in patients with acute cerebral infarction were significantly higher than those in the normal control group (P <0.01). After 2 weeks of treatment, the CRP levels were significantly decreased, and the butylphthalide group was lower than the conventional treatment group, The difference between the two groups was significant (P <0.01). Conclusion The early use of butylphthalide can significantly reduce the serum levels of CRP in patients with acute cerebral infarction, reduce the inflammatory response, and improve the prognosis of cerebral infarction has an important value.