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目的探讨乌司他丁对重度脓毒症患者淋巴细胞计数及各亚群比例变化的影响。方法观察重度脓毒症患者的APECHEⅡ评分及SOEA评分,以及淋巴细胞计数和各亚群细胞比例的变化情况。结果经治疗患者较高的APECHEⅡ评分及SOEA评分水平降低,淋巴细胞计数回升,比例改善,以乌司他丁组改善更明显。革兰氏阳性细菌感染患者表现出更明显而持久的淋巴细胞亚群改变。结论重度脓毒症患者淋巴细胞计数下降且各亚群比例异常,乌司他丁有助于纠正该异常。
Objective To investigate the effects of ulinastatin on lymphocyte count and the proportion of subgroups in patients with severe sepsis. Methods Severe sepsis patients APECHE Ⅱ score and SOEA score, as well as lymphocyte count and the proportion of each subpopulation changes. Results The higher APECHEⅡscore and SOEA score of the treated patients decreased, the lymphocyte count increased and the proportion improved, especially in the ulinastatin group. Gram-positive bacterial infections show a more pronounced and sustained change in lymphocyte subsets. Conclusion The patients with severe sepsis have decreased lymphocyte count and abnormal proportion of each subgroup, and ulinastatin may help to correct the abnormality.