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目的 :观察给L 甲状腺素及或给甲硫咪唑抑制甲状腺功能 ,对实验性脑梗塞的影响。方法 :小鼠给药L 甲状腺素、甲状腺干粉和甲硫咪唑造成三种不同的甲状腺功能水平。并观察他们对中脑动脉阻塞后反应来评价他们对缺血性损伤的作用。结果 :血清T3和T4在L 甲状腺素组和甲状腺干粉组有所增加。甲硫咪唑组给药 30d后 ,T3值下降 ,T4值不变。L 甲状腺素和甲状腺干粉组使梗塞区增加 ,LDH活力和MDA增加。甲硫咪唑组梗塞范围下降。L 甲状腺素使神经病变减轻。小结 :L 甲状腺素加重由MCAO所致的脑梗塞。
Objective: To observe the effects of L-thyroxine and methimazole on thyroid function and experimental cerebral infarction. METHODS: Three different thyroid function levels were induced in mice by administering L-thyroxine, thyroid dry powder and methimazole. And observed their response to occlusion of the middle cerebral artery to evaluate their effect on ischemic injury. Results: Serum T3 and T4 increased in L thyroxine group and thyroid dry powder group. Methimazole group administered 30d, T3 decreased, T4 unchanged. L thyroid hormone and thyroid dry powder group increased infarct size, LDH activity and MDA increased. Methimazole group decreased infarct size. L Thyroxine to reduce neuropathy. Summary: L thyroxine aggravates cerebral infarction caused by MCAO.