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目的检测表皮-钙黏附素(E-CD)、α-连接素(α-cat)在结直肠癌中的表达及探讨其与结直肠癌临床病理特征的关系。方法应用免疫组织化学的方法(EnVision法)检测E-CD、α-cat在115例结直肠癌、19例结直肠腺瘤、10例正常结直肠黏膜中的表达,分析E-CD、α-cat与结直肠癌浸润、转移和预后之间的关系。结果E-CD、α-cat在正常结直肠黏膜中呈保存型表达。在结直肠腺瘤中,E-CD、α-cat保存型表达减低。在结直肠癌中21.7%的E-CD和42.6%的α-cat呈保存型表达;E-CD、α-cat表达与肿瘤浸润深度、静脉侵犯、淋巴管侵犯、淋巴结侵犯、Dukes分期显著相关(P<0.05);E-CD、α-cat表达与结直肠癌患者生存率显著相关。结论E-CD、α-cat表达下调的结直肠癌病期晚、预后差,α-cat的表达类型是患者生存率的独立预后指标。
Objective To detect the expression of epidermal-cadherin (E-CD) and α-catenin (α-cat) in colorectal cancer and to investigate its relationship with the clinicopathological features of colorectal cancer. Methods The expressions of E-CD and α-cat in 115 cases of colorectal cancer, 19 cases of colorectal adenoma and 10 cases of normal colorectal mucosa were detected by immunohistochemistry (EnVision) cat and colorectal cancer infiltration, metastasis and prognosis. Results E-CD and α-cat were conserved in normal colorectal mucosa. In colorectal adenoma, E-CD, α-cat preservation-type expression decreased. In colorectal cancer, 21.7% of E-CD and 42.6% of α-cat were expressed in preserved form. The expressions of E-CD and α-cat were significantly correlated with the depth of invasion, venous invasion, lymphatic invasion, lymph node invasion and Dukes staging (P <0.05). The expression of E-CD and α-cat was significantly correlated with the survival rate of patients with colorectal cancer. Conclusions The prognosis of colorectal cancer with E-CD and α-cat expression down-regulation is late and the prognosis is poor. The expression of α-cat is an independent prognostic indicator of patient survival.