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目的 :探讨补肾中药对小儿肾病综合征不同治疗阶段血清皮质醇的影响。方法 :单纯性肾病综合征患儿 72例 ,其中中药佐治组 38例 ,泼尼松组 34例 ;正常对照组 2 0例。两组病人分别于治疗前、激素足量阶段、减量阶段、停药之前测血清皮质醇。随访观察近 3年。结果 :①全部病人治疗前血清皮质醇均低于正常对照组 (P <0 0 1)。②中药佐治组在疗程各阶段血清皮质醇均高于泼尼松组 (分别为P <0 0 1、P <0 0 1、P<0 0 5 )。③中药佐治组复发例次明显少于泼尼松组。结论 :补肾中药对肾病患儿的肾上腺皮质功能有保护作用 ,该作用与减少肾病复发有关
Objective: To investigate the effect of tonifying kidney on serum cortisol in children with nephrotic syndrome at different treatment stages. Methods: 72 cases of simple nephrotic syndrome in children, including traditional Chinese medicine treatment group 38 cases of prednisone group 34 cases; normal control group 20 cases. Two groups of patients were treated before treatment, hormone sufficient stage, reduction phase, serum cortisol before stopping. Follow-up observation of nearly 3 years. Results: All the patients before treatment serum cortisol were lower than the normal control group (P <0.01). ② The levels of serum cortisol in the TCM treatment group were significantly higher than those in the prednisone treatment group (P <0.01, P <0.01, P <0.05, respectively). ③ Chinese medicine treatment group relapse cases were significantly less than the prednisone group. Conclusion: Bushen Chinese medicine has a protective effect on adrenocortical function in children with nephropathy, and this effect is related to reducing relapse of nephropathy