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孕16～18周母血清甲胎蛋白(AFP)含量≥2.5MoM(中位数的倍数)大约仅3％为正常胎儿,而异常妊娠无脑儿占90％,开放性脊柱裂80％,前腹壁缺损40％。本研究测定了孕10～14周无脑儿及脐膨出胎儿母血清AFP值,目的是了解在此孕周AFP是否升高。 在10～14周测定了超声筛查出来的畸形儿[9例无脑儿,7例脐膨出(内含肝脏),2例脊柱裂胎儿]的母血清APF值以及100例正常对照组孕妇血清AFP值。采用敏感的放免测
Maternal serum alpha-fetoprotein (AFP) levels ≥ 2.5MoM (multiples of median) from 16 to 18 weeks of gestation Approximately 3% are normal fetuses, whereas anomalies have 90% of anencephaly children, 80% of open spina bifida, Abdominal wall defects 40%. The aim of this study was to determine the AFP value of fetal brain and omphalocele fetuses from 10 to 14 weeks of gestation to determine if AFP is elevated during the first trimester of pregnancy. The APF values of maternal serum obtained from sonographic screening of malformations [9 children without brains, 7 with umbilical swelling (including liver), 2 with spina bifida] and 10 normal pregnant women were measured at 10 to 14 weeks Serum AFP values. Sensitive radioactive test