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目的:观察腹腔镜手术联合药物治疗青春期子宫内膜异位症的疗效,探讨治疗青春期子宫内膜异位症的最佳方案。方法:2006年～2010年我院收治的32例青春期子宫内膜异位症患者均行腹腔镜手术治疗,按术后用药分为口服避孕药组(18例)和戈舍瑞林延长注射组(14例),比较两组患者的症状缓解率、复发率及药物副反应。结果:口服避孕药组症状有效率为55.56%,复发率为27.78%,在症状缓解及控制复发方面均显著低于戈舍瑞林组(92.86%,7.14%)(P<0.05)。两组治疗过程中均有不良反应,避孕药组主要为不规则阴道出血、胃肠道反应、乳房胀痛、体重增加,戈舍瑞林组主要为潮热、多汗等更年期样症状,通过反加治疗后均缓解。结论:青春期子宫内膜异位症患者腹腔镜术后,联合戈舍瑞林延长注射可取得确切疗效,有效缓解症状,降低复发率。
Objective: To observe the efficacy of laparoscopic surgery combined with drug treatment of adolescent endometriosis, to explore the best treatment for adolescent endometriosis. Methods: Thirty-two cases of adolescent endometriosis admitted to our hospital from 2006 to 2010 underwent laparoscopic surgery. According to the postoperative medication, they were divided into oral contraceptive group (n = 18) and goserelin extended injection group (14 cases). The symptom remission rate, relapse rate and drug side effects were compared between the two groups. Results: The effective rate of oral contraceptives was 55.56%, the recurrence rate was 27.78%, and was significantly lower than that of goserelin group (92.86%, 7.14%) in symptom relief and control recurrence (P <0.05). Both groups had adverse reactions in the course of treatment. The contraceptive group was mainly irregular vaginal bleeding, gastrointestinal reactions, breast pain and weight gain. The goserelin group was mainly menopausal symptoms such as hot flashes, hyperhidrosis, Anti-plus treatment were relieved. Conclusion: After laparoscopic surgery for adolescent endometriosis, prolonged injection combined with goserelin can achieve the exact effect, effectively relieve symptoms and reduce the recurrence rate.