观察９４例胃癌病人手术切除的肿瘤组织癌胚抗原（ＣＥＡ）免疫酶标的表达，检测４５例胃癌病人术前血清ＣＥＡ浓度，并随访２１例术后的胃癌病人。结果提示：血清ＣＥＡ水平与肿瘤生长部位及浸润深度关系不大，但与肿瘤大小、组织类型及血管和淋巴管是否累及有关。４５例胃癌病人同时进行组织及血清ＣＥＡ的比较性研究，发现免疫组化ＣＥＡ表达的阳性率要比血清ＣＥＡ检测的阳性率高得多（Ｐ＜０．０１）。２１例胃癌病人的随访，早期胃癌５年生存率为８３．３％（５／６），晚期胃癌为３３．３％（５／１５），血清ＣＥＡ浓度轻度升高或免疫酶标弱阳性预后较好；血清浓度明显升高的２例，于５年内死亡；肿瘤组织内ＣＥＡ呈强阳性者，术后生存率低，免疫组化强度与肿瘤预后呈明显正相关（Ｐ＜０．０５）。通过两种方法比较研究提示：血清浓度明显升高特别是组织内ＣＥＡ表达强阳性，具有估计预后的意义；且ＣＥＡ免疫组化显色比血清检测更为敏感（Ｐ＜０．０１），可作为推测胃癌预后的一项指标。 Observe the expression of tumor tissue carcinoembryonic antigen (CEA) immunoenzymes in 94 patients with gastric cancer after surgical resection, detect the preoperative serum CEA concentration in 45 patients with gastric cancer, and follow up 21 patients with postoperative gastric cancer. The results suggest that serum CEA levels have little to do with the site of tumor growth and depth of invasion, but are related to tumor size, tissue type, and involvement of vascular and lymphatic vessels. A comparative study of tissue and serum CEA was performed in 45 patients with gastric cancer. It was found that the positive rate of immunohistochemical CEA expression was much higher than that of serum CEA (P<0.01). In the follow-up of 21 patients with gastric cancer, the 5-year survival rate was 83.3% (5/6) in early gastric cancer, 33.3% (5/15) in advanced gastric cancer, and the serum CEA concentration was slightly elevated or the immunoenzyme was weakly positive. The prognosis was good; 2 cases with significantly elevated serum concentrations died within 5 years; CEA was strongly positive in the tumor tissue, and the postoperative survival rate was low. The immunohistochemical intensity was positively correlated with the prognosis of the tumor (P<0.05). ). The comparison between the two methods showed that the serum concentration was significantly elevated, especially in the tissue, and that CEA expression was strongly positive, which had a significant prognostic significance. CEA immunohistochemical staining was more sensitive than serum detection (P<0.01). As an indicator of the prognosis of gastric cancer.