论文部分内容阅读
自从1948年Albright首次提出糖尿病(DM)可致骨改变以来,越来越多的学者开始研究DM骨改变及其机制。笔者现将近年来的研究成果作一综述。 DM对矿物质代谢的影响:DM对钙磷代谢的影响已被大量的动物实验和临床研究所证实。有人观察到DM性骨质疏松与骨基质及骨矿物质代谢紊乱有关。其发病机制包括:①多数人认为,高血糖时大量葡萄糖从尿液排出,渗透性利尿作用,将大量钙、磷、镁离子排出体外而使其血液浓度降低;低钙、低镁刺激甲状旁腺功能亢进,使甲状旁腺素(PTH)分泌增加,溶骨作用增强,出现骨吸收增加,骨量减少。②胰岛素不
Since Albright first proposed diabetes mellitus (DM) -based bone alteration in 1948, more and more scholars began to study the changes of DM bone and its mechanism. The author now summarizes the research results in recent years. Effect of DM on Mineral Metabolism: The effect of DM on calcium and phosphorus metabolism has been confirmed by a large number of animal experiments and clinical studies. It was observed that DM osteoporosis and bone matrix and bone mineral metabolism disorders. The pathogenesis include: ① most people think that when a lot of glucose excretion from the urine of high blood sugar, osmotic diuretic effect, a large number of calcium, phosphorus and magnesium ions excreted to lower blood concentration; low calcium, low magnesium stimulated parathyroid Hyperthyroidism, so that increased secretion of parathyroid hormone (PTH), enhanced osteolytic effect, there was an increase in bone resorption, decreased bone mass. ② insulin is not