论文部分内容阅读
目的 探讨茶色素对早期糖尿病肾病患者 2 4h尿液内皮素 (UET)排泄的影响及其临床意义。方法 将 6 5例早期糖尿病肾病患者随机分成对照组和治疗组两组 ,对照组采用常规治疗 ,治疗组在常规治疗的基础上给予茶色素治疗 ,3次 /d ,每次 0 2 4g口服。两组疗程均为 8周。通过放射免疫法测定两组患者治疗前后 2 4hUET、尿白蛋白的排泄率 (UAER)变化。结果 糖尿病肾病 (DN)患者 2 4hUET排泄量显著高于健康人 (P <0 0 1) ,治疗组治疗后 2 4hUET、UAER较治疗前明显降低 (P <0 0 1,P <0 0 1) ,对照组治疗后 2 4hUET、UAER较治疗前无明显变化 (P >0 0 5 ) ,治疗组治疗 8周后 2 4hUET、UAER较对照组显著下降 (P <0 0 1) ,2 4h尿ET降低与UAER降低呈正相关 (P <0 0 1)。结论 DN患者UET明显增多 ,茶色素可能通过抑制DN患者体内 ,尤其肾脏产生ET致尿液排泄ET减少 ,从而可对DN患者肾脏功能起到一定的改善和保护作用 ,为临床治疗DN患者提供了新的途径
Objective To investigate the effect of tea pigment on excretion of urinary excretion of endothelin (UET) in patients with early diabetic nephropathy and its clinical significance. Methods Sixty-five patients with early diabetic nephropathy were randomly divided into control group and treatment group. The control group was treated with conventional therapy. The treatment group was treated with tea pigment on the basis of routine treatment for 3 times daily for 24 hours. The two groups were treated for 8 weeks. Radioimmunoassay was used to determine the changes of urinary albumin excretion rate (UAER) at 24 hours after treatment in both groups. Results The urinary excretion of 24 hours in patients with diabetic nephropathy was significantly higher than that in healthy subjects (P <0.01). The UAER of 24 hours after treatment in treatment group was significantly lower than that before treatment (P <0.01, P <0.01) (P <0.05). In the control group, 24 h UET and UAER had no significant changes (P> 0.05), but UAER decreased significantly (P <0.01) and UAER The decrease was positively correlated with the decrease of UAER (P <0.01). Conclusions The UET in patients with DN is obviously increased. Tea pigment may reduce or eliminate the excretion of ET in the patients with DN, especially the kidneys, which may improve and protect the renal function of DN patients. It provides the clinical treatment of patients with DN New way