当前,全球结核病疫情日益恶化,发达国家或发展中国家结核病均呈上升趋势,结核性脑膜炎TBM发病率有所增加。随着抗结核药物应用,使预后有很大改观,但TBM的病死率和致残率仍很高,欧美国家报告TBM病死率高达15％～36％,病死率高的主要原因为未能早期诊断和及时治疗。因此探讨结脑的早期诊断有积极的意义。 Currently, the global epidemic of tuberculosis is worsening. Tuberculosis in both developed and developing countries is on the rise. The incidence of TB meningitis has been on the rise. With the application of anti-TB drugs, so that the prognosis has greatly improved, but the mortality and disability of TBM is still high, the European and American countries reported TBM mortality as high as 15% to 36%, the main reason for high mortality was failure to early Diagnosis and timely treatment. Therefore, to explore the early diagnosis of knot brain has a positive meaning.