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目的研究吲哚美辛对大鼠胃酸分泌及胃蛋白酶活力的影响及其作用机制。方法大鼠分为对照组和吲哚美辛低、中、高剂量组。测定各组大鼠胃酸分泌量及胃蛋白酶活力,测定血清胃泌素含量。结果吲哚美辛可显著增加胃酸分泌量、增加胃酸分泌速度及增加胃蛋白酶活力,促进胃泌素分泌。结论吲哚美辛可显著促进胃酸分泌,增加胃蛋白酶活力,这与其促进胃秘素分泌有关。
Objective To study the effect of indomethacin on gastric acid secretion and pepsin activity in rats and its mechanism. Methods Rats were divided into control group and indomethacin low, medium and high dose groups. Gastric acid secretion and pepsin activity of rats in each group were measured and serum gastrin levels were measured. Indomethacin significantly increased gastric acid secretion, increased gastric acid secretion and increased pepsin activity, and promote the secretion of gastrin. Conclusion Indometacin can significantly promote the secretion of gastric acid and increase the activity of pepsin, which is related to the promotion of gastric secretin secretion.