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目的探讨鞍区孤立性纤维性肿瘤的临床病理学特点及诊断要点。方法对1例鞍区孤立性纤维性肿瘤进行临床资料、影像学、病理形态学观察及免疫组化检测,并结合文献对其诊断及鉴别诊断进行探讨。结果患者女性43岁。MIR提示鞍区占位,肿瘤向鞍上及海绵窦侵犯。镜下可见梭形细胞结构,局部细胞密度较高,可见红染无细胞区及退变,核分裂平均<2个/10HPF,细胞呈编织状排列。免疫组化:CD34、CD99、bcl-2和vimentin(+),S-100和EMA(-)。结论发生于鞍区的孤立性纤维性肿瘤罕见。由于其发病部位特殊,需将临床资料、影像学资料与病理学及免疫组化特点相结合进行诊断,并注意与垂体细胞瘤、神经鞘瘤等鉴别。
Objective To investigate the clinicopathological features and diagnosis points of solitary fibrous tumors in the sellar region. Methods One case of solitary fibrous tumor in the sellar region was studied by clinical data, imaging, histopathological observation and immunohistochemistry, and its diagnosis and differential diagnosis were discussed. Results The patient was 43 years old. MIR prompt saddle area, the tumor to the suprasellar and cavernous sinus violations. Microscopic spindle cell structure can be seen, the higher the local cell density, visible red cell free zone and degeneration, mitotic average <2 / 10HPF, the cells were woven arrangement. Immunohistochemistry: CD34, CD99, bcl-2 and vimentin (+), S-100 and EMA (-). Conclusion Solitary fibrous tumors occur rarely in the sellar region. Because of its special part of the disease, the clinical data, imaging data and pathology and immunohistochemical characteristics of the combination of diagnosis, and pay attention and pituitary tumor, schwannoma and other identification.