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目的探讨影响胃癌周围淋巴结转移的病理因素,为合理的胃癌根治术提供依据。方法收集天津医科大学总医院222例切除胃癌原发灶患者的病理资料,对肿瘤原发部位、大体形态、细胞来源、分化程度、肿瘤直径以及浸润深度与淋巴结转移之间的关系进行统计学分析。结果单因素分析发现肿瘤直径大小、浸润深度、分化程度与淋巴结转移相关,而多因素分析则显示分化程度不是胃癌发生淋巴结转移的独立危险因素。原发部位、大体分型、细胞来源与淋巴结转移无关。结论胃癌根治术时应根据肿瘤直径与浸润深度选择合理的淋巴结清扫范围。
Objective To investigate the pathological factors affecting the lymph node metastasis of gastric cancer and provide the basis for a reasonable radical operation of gastric cancer. Methods Totally 222 patients with primary gastric cancer resected from Tianjin Medical University General Hospital were enrolled in this study. The primary site, gross morphology, cell origin, differentiation degree, tumor diameter, depth of invasion and lymph node metastasis were analyzed statistically . Results Univariate analysis showed that tumor diameter, depth of invasion and differentiation were related to lymph node metastasis. Multivariate analysis showed that the degree of differentiation was not an independent risk factor for lymph node metastasis in gastric cancer. Primary site, general classification, cell source and lymph node metastasis has nothing to do. Conclusion Radical gastrectomy should be based on tumor diameter and depth of invasion to select a reasonable range of lymph node dissection.