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目的探讨半胱氨酸天冬氨酸蛋白酶-3(Caspase-3)与Clusterin的表达及其与血管瘤消退的关系。方法采用免疫组化SP法检测Caspase-3与Clusterin在34例血管瘤和6例正常皮肤组织中的表达。结果Caspase-3与Clusterin在34例血管瘤组织中阳性表达率,增生期分别为31·3%、81·3%,消退期分别为72·2%、38·9%,而在正常皮肤均不表达,其中,Caspase-3在增生期中的表达低于消退期,差异有统计有统计学意义(P<0·05),Clusterin在增生期中表达高于消退期,差异有统计学意义(P<0·05)。结论Clusterin蛋白可能通过抑制细胞凋亡在血管瘤的发生发展中发挥重要作用,且其表达与Caspase-3的异常表达密切相关。
Objective To investigate the expression of Caspase-3 and Clusterin and its relationship with the regression of hemangiomas. Methods The expression of Caspase-3 and Clusterin in 34 hemangiomas and 6 normal skin tissues was detected by immunohistochemical SP method. Results The positive rates of Caspase-3 and Clusterin in 34 hemangiomas were 31.3% and 81.3%, respectively, and the regression rates were 72.2% and 38.9% respectively. In normal skin, The expression of Caspase-3 in the proliferative phase was lower than that in the regression phase, the difference was statistically significant (P <0.05). The expression of Clusterin was higher in the proliferative phase than in the regression phase (P <0.05) <0 · 05). Conclusions Clusterin protein may play an important role in the development of hemangiomas by inhibiting apoptosis, and its expression is closely related to the abnormal expression of Caspase-3.