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目的:观察稳心颗粒联合美托洛尔治疗心律失常的临床疗效和不良反应。方法:将收治的心律失常患者128例随机分为研究组和对照组,每组64例,研究组给予口服稳心颗粒9g/次,3次/天,美托洛尔12.5mg/次,2次/天;对照组给予口服美托洛尔12.5mg/次,2次/天,疗程均为4周,所有患者治疗前后均行心电图及24h动态心电图检查。结果:治疗4周后研究组总有效率为92.2%,对照组总有效率为71.9%,数据间差异有统计学意义(P<0.05)。治疗前两组24h动态心电图时域指标比较无统计学差异(P>0.05);治疗4周后两组时域指标均有所升高,研究组正常窦性心搏间期标准差(SDNN)、窦性心搏间期平均标准差(SDANN),全程每5minRR剑气标准差(SDNN-index)较对照组升高更为显著,数据间差异有统计学意义(P<0.05)。两组患者治疗期间未见严重不良反应。结论:稳心颗粒联合美托洛尔治疗心律失常疗效较好,可以明显改善患者心律失常及心律变异性,不良反应较少。
Objective: To observe the clinical efficacy and adverse reactions of Wenxin Granule combined with metoprolol in the treatment of arrhythmia. Methods: One hundred and twenty-eight patients with arrhythmia were randomly divided into study group and control group, with 64 cases in each group. The study group was given oral Wenxin Granule 9g / time, 3 times / day, metoprolol 12.5mg / time, Times a day; the control group was given metoprolol 12.5mg / time, 2 times / day, the course of treatment was 4 weeks, all patients underwent electrocardiogram and 24h Holter examination before and after treatment. Results: After 4 weeks of treatment, the total effective rate was 92.2% in the study group and 71.9% in the control group. The difference was statistically significant (P <0.05). There was no significant difference in 24 hour dynamic electrocardiogram (ECG) time domain before treatment between the two groups (P> 0.05). After 4 weeks of treatment, both time domain indexes were increased in both groups. The normal sinus gap time (SDNN), sinus heart The standard deviation of stroke duration (SDANN) was significantly higher than that of the control group every 5min, and the difference was statistically significant (P <0.05). Two groups of patients during the treatment of serious adverse reactions. Conclusion: Wenxin granule combined with metoprolol has a better curative effect on arrhythmia, which can obviously improve the arrhythmia and arrhythmia in patients with less adverse reactions.