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目的本文作者观察了ｒｈＴＰＯ和ｒｈＧＣＳＦ对急性放射病猴的治疗效果，旨在为造血因子的临床应用提供理论依据。方法正常雄性成年猕猴２０只，随机分为ｒｈＴＰＯ１０μｇ·ｋｇ－１·ｄ－１、ＧＣＳＦ１０μｇ·ｋｇ－１·ｄ－１、ＴＰＯ＋ＧＣＳＦ和照射对照４组。动物照射的吸收剂量为５０Ｇｙ（３００ｋＶＸ射线，吸收剂量率为０２０～０２２Ｇｙ／ｍｉｎ）；给药方法均为皮下注射，连续给药２１天。结果①外周血小板：照后第７天ＴＰＯ治疗组开始下降，第１０天达最低值（４５％，以照前值为１００％，下同），第１４天达照前值水平，第２１天达最高值（３１１％），第３０天仍为２６３％。ＧＣＳＦ治疗组第９天仅为照前值的１０％，照后第３０天接近照前水平（９２％）。对照组照后第７天开始迅速下降，第１６天达最低值（９％），仅为ＴＰＯ治疗组的５９％（Ｐ＜００１），第３０天（８０％）仍未恢复到照前值水平。②外周血网织红细胞百分比：４组动物照后均迅速下降，ＴＰＯ治疗组于照后第８天达最低值（１１％），低于照前值５０％的时间为８天，第１２天开始迅速回升，第２０天达最高值（４０２％）。ＧＣＳＦ治疗组及对照组动物下降程度更为迅速，第９天分别为照前?
The purpose of this article The authors observed rhTPO and rhG CSF treatment of acute radiation sickness monkey aims to provide a theoretical basis for the clinical application of hematopoietic factors. Methods Twenty male adult macaques were randomly divided into 4 groups: rhTPO 10μg · kg-1 · d-1, G-CSF 10μg · kg-1 · d-1, TPO + GCSF and irradiation control group. The absorbed dose of animal irradiation was 5 0Gy (300kVX ray, absorbed dose rate of 0 20 ~ 0 22Gy / min); administration methods are subcutaneous injection, continuous administration of 21 days. Results (1) Peripheral platelets: The TPO treatment group began to decline on the 7th day after the irradiation, reaching the lowest value on the 10th day (45%, taking the pre-value of 100%, the same below), reaching the pre-irradiation level on the 14th day, Reaching the highest value (311%), still 263% on the 30th day. G-CSF treatment group on the 9th day only 10% of the value of the pre-irradiation, the day after irradiation 30h close to the pre-exposure level (92%). The control group began to decline rapidly on the 7th day, reaching the lowest value on the 16th day (9%), only 59% (P <001) of the TPO group and not recovering on the 30th day (80%) To the value before the level. ② The percentage of reticulocyte in peripheral blood was decreased rapidly in all the four groups. The TPO group reached the lowest value (11%) on the 8th day after irradiation and 8 days lower than the 50% value before the irradiation. On the 12th day The rapid rebound started to reach the highest value on the 20th day (402%). G-CSF treatment group and control animals decreased more rapidly, the first 9 days were as before?