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对原发性高血压和高血压伴肥胖患者采用口服葡萄糖耐量试验(OGTT)观察。结果高血压伴肥胖组空腹胰岛素(FSI)、C肽(FS-CP),OGTT后1小时血糖(PBG)、胰岛素(PSI)、C肽(PS-CP)及PSI/PS-CP比值显著高于原发性高血压组及对照组,PBG/PSI比值显著低于原发性高血压组及对照组。多因素分析显示高血压病人的PSI与舒张压呈显著正相关。高血压伴肥胖病人PSI的异常升高除与胰岛β细胞分泌增加有关外。还与肝脏对胰岛素清除率下降有关。
Oral glucose tolerance test (OGTT) was used in patients with essential hypertension and hypertension associated with obesity. Results The ratio of fasting insulin (FSI), C-peptide (FS-CP), one hour post-OGTG (PBG), insulin (PSI), C peptide (PS-CP) and PSI / PS-CP were significantly higher in hypertensive patients with obesity In the primary hypertension group and the control group, PBG / PSI ratio was significantly lower than that of the primary hypertension group and the control group. Multivariate analysis showed that there was a significant positive correlation between PSI and diastolic blood pressure in hypertensive patients. Hypertension with obesity in patients with abnormal PSI abnormal increase in addition to the increase of pancreatic β-cell secretion. Also with the liver on the reduction of insulin clearance related.