碳苷是一类苷元和糖以碳碳键相连的化合物,广泛存在于自然界。其中许多具有生理活性,如黄酮碳苷,对心血管疾病有效。我们在合成碳苷时发现,格氏试剂和取代的卤代糖反应,多数情况下给出碳苷的α,β体混合物。因此α,β异构体的分离就成了碳苷研究的关键步骤,传统的常压和低压柱层析方法很难将α,β异构体完全分开, Carbon glycosides are a group of glycosidic compounds and carbohydrates linked to carbon bonds, widely found in nature. Many of them are physiologically active, such as flavonoid glycosides, which are effective against cardiovascular disease. We found in the synthesis of carbon glycosides, Grignard reagents and substituted halogenated sugar reaction, in most cases given carbon glycosides α, β body mixture. Therefore, the separation of α, β isomers has become a key step in the study of glycosides. Conventional atmospheric and low pressure column chromatography methods are difficult to completely separate α, β isomers,