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目的 :探讨用于喉癌患者术后复发监测及预后评估的参考指标。方法 :对 34例喉癌患者 (喉癌组 )分别检测术前和术后第 7天、第 30天、第 90天的血清 IL- 2、s IL- 2 R、TNF- α水平。并以 2 0例健康人进行对照 (对照组 )。结果 :喉癌组术前的血清 s IL- 2 R与 TNF- α水平明显高于对照组 (P <0 .0 1) ,IL- 2两组无差异。随访 3个月 ,2 9例未复发患者 (未复发组 ) s IL- 2 R、TNF- α水平术后第 7天稍高于术前 ,但无统计学意义 ;术后第 30天和第 90天逐渐下降 ,其中 s IL- 2 R水平下降更为明显 ,IL- 2无明显变化。 5例复发患者 (复发组 ) s IL- 2 R、TNF- α水平术后第 30天低于术前 ,第 90天又升高 ;而 IL- 2则逐渐下降。结论 :检测喉癌患者手术前后的血清细胞因子的动态变化 ,对病情的监测及预后的判定有一定的参考价值。
Objective: To explore the reference index for postoperative recurrence monitoring and prognosis evaluation in patients with laryngeal cancer. Methods: Thirty-four patients with laryngocarcinoma (laryngocarcinoma) were enrolled in the study. Serum levels of IL-2, IL-2R and TNF-α were measured before operation, 7 days, 30 days and 90 days respectively. Twenty healthy controls were included (control group). Results: The serum levels of sIL-2R and TNF-α in the laryngocarcinoma group were significantly higher than those in the control group (P <0.01). There was no difference between the two groups. After 3 months of follow-up, the levels of IL-2R and TNF-α in 29 non-recurrent patients (non-recurrent group) were slightly higher than preoperation on the 7th day after operation, but no significant difference was found between the 30th and the After 90 days, the level of sIL-2R decreased more obviously, and there was no obvious change of IL-2. The levels of IL-2R and TNF-α in 5 relapsed patients (relapse group) were lower than preoperative day 30 and 90th day after operation, while the levels of IL-2 decreased gradually. Conclusion: The dynamic changes of serum cytokines in patients with laryngeal cancer before and after operation have some reference value for monitoring the disease and prognosis.