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目的探讨冠心病(CHD)患者血清同型半胱氨酸(HCY)、尿酸(UA)、胆红素水平变化及意义。方法采用全自动生化分析仪检测65例冠心病患者血清HCY、UA及胆红素水平,并与50例对照组比较分析。结果冠心病组和正常对照组血清HCY、UA、总胆红素(TBIL)、直接胆红素(DBIL)分别为(42.0±8.0)、(387.0±25.0)、(7.8±1.9)、(2.4±0.6)μmol/L;(13.0±6.0)、(256.0±16.0)、(13.5±2.1)、(4.0±0.8)μmol/L,HCY、UA均较对照组增高(P<0.05),TBIL、DBIL均较对照组降低(P<0.05)。结论 HCY、UA与冠心病的发生呈正相关,胆红素与冠心病的发生呈负相关。
Objective To investigate the changes of serum homocysteine (HCY), uric acid (UA) and bilirubin in patients with coronary heart disease (CHD). Methods The levels of serum HCY, UA and bilirubin in 65 patients with coronary heart disease were detected by automatic biochemical analyzer and compared with 50 control subjects. Results The serum levels of HCY, UA, total bilirubin (TBIL) and direct bilirubin (DBIL) in CHD group and normal control group were 42.0 ± 8.0, 387.0 ± 25.0, 7.8 ± 1.9, 2.4 (P <0.05). The levels of TBIL, IL-6, IL-6, IL-6, DBIL than the control group decreased (P <0.05). Conclusions There is a positive correlation between HCY, UA and the incidence of coronary heart disease. The incidence of coronary heart disease is negatively correlated with bilirubin.